Current criteria for the diagnosis and treatment of multiple myeloma (literature review)
Keywords:multiple myeloma, Bence Jones protein, M protein, high-dose chemotherapy, autologous stem cell transplantation, review
AbstractMultiple myeloma (MM) is about 1 % of all malignancies and 10–15 % in the structure of hemoblastoses. In most patients, MM develops as a result of monoclonal gammopathy of undetermined significance, which is usually diagnosed accidentally in 3–5 % of people over 50 years of age. The average risk of MM progression is about 1 % per year. Thanks to modern diagnostic methods, the diagnosis of MM is now being established faster, which allows the treatment to be started as soon as possible. Polychemotherapy plays a leading role in the comprehensive treatment of MM. At the present stage, novel, particularly targeted, drugs are being developed, the use of which is more effective. An important place in the treatment of MM belongs to high-dose chemotherapy followed by transplantation of stem cells. Some problems in the diagnosis and treatment of patients with MM remain unresolved, so they need more detailed revision, further development of pharmacological drugs and treatment regimens, additional clinical studies. The literature review is based on clinical research data, guidelines of the European Society for Medical Oncology, National Comprehensive Cancer Network, obtained using the PubMed search resource.
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