Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of stage III–IV primary ovarian cancer


  • Ya.S. Nazarov Bogomolets National Medical University, Kyiv, Ukraine
  • V.I. Kopetskyi National Cancer Institute, Kyiv, Ukraine
  • Ye.A. Shudrak National Cancer Institute, Kyiv, Ukraine



ovarian cancer, stage III–IV ovarian cancer, cytoreductive surgery, debulking, hyperthermic intraperitoneal chemotherapy, review


Ovarian cancer (OC) is the most aggressive female genital cancer, which is characterized by implant growth, visceral and parietal peritoneal carcinomatosis and damage to the abdominal cavity and retroperitoneal space. Every year, more than 290,000 new cases of OC and 180,000 deaths from this pathology are registered worldwide. Stage III–IV OC is a primary diagnosis in 80 % of the patients. Classic procedures like radical hysterectomy and omentectomy are not sufficient for the recovery of such patients. Additional interventions in pelvic, extrapelvic and upper abdomen organs might be required. Such procedures demand high-skill surgeon techniques. Primary complete cytoreduction which imply complete removal of all masses followed by the adjuvant chemotherapy is the gold standard in the treatment for stage III–IV OC. Hyperthermic intraperitoneal chemotherapy is the novel option in the treatment of OC, which could increase overall and disease-free survival rate in these patients.


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