Prolactin, its physiological function and role in breast oncogenesis (a review of the literature)


  • V.V. Lihostaieva Bogomolets National Medical University, Kyiv, Ukraine
  • O.S. Zotov Bogomolets National Medical University, Kyiv, Ukraine
  • M.V. Braitsara Bogomolets National Medical University, Kyiv, Ukraine



breast cancer, prolactin, prolactin receptors, hyperprolactinemia, review


Breast cancer is the most frequent cancer among wo­men, impacting 2.1 million individuals each year, and also causes the greatest number of cancer-related deaths among women. Prolactin, known as not only a hormone involved in normal breast development and lactation, but also a cytokine, has been hypothesized to be important in the etiology of breast cancer. The literature review contains the data regarding the physiological role of prolactin, as well as its synthesis, regulation, pathogenesis, and clinical manifestations of hyperprolactinemic states. We have described the results of the relevant epidemiological trials on the role of prolactin in breast oncogenesis, particularly in different molecular types of breast cancer. The publications (reviews, original articles, results of in vitro, in vivo and clinical studies, meta-analyses) used in this work were analyzed using the search databases such as PubMed, MEDLINE, Medscape.

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