Clinical significance of anticancer vaccines (literature review)

Authors

  • R.V. Liubota Bogomolets National Medical University, Kyiv, Ukraine
  • Zh.P. Yakovets Bogomolets National Medical University, Kyiv, Ukraine
  • R.I. Vereshchako Bogomolets National Medical University, Kyiv, Ukraine
  • M.F. Anikusko Kyiv City Clinical Cancer Center, Kyiv, Ukraine
  • I.I. Liubota Kyiv City Clinical Cancer Center, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2663-3272.4.2.2021.238669

Keywords:

anticancer vaccines, cancer immunotherapy, personalized therapy, tumor-associated antigens, review

Abstract

During the past few decades, the advances in cancer immunotherapy have revived interest in the potential use of vaccines for the malignant tumor treatment. Tumor-associated antigens, which are abnormally expressed by tumor cells, are of decisive importance in the development of anticancer vaccines. Through the stimulation of immunological memory, therapeutic anticancer vaccines can result in long-term remission or healing patients. Therapeutic anticancer vaccines due to the potential safety, specificity and duration of effect can become an alternative to or increase the effectiveness of existing immunotherapies. This article presents data on the tumor antigen structure, characteristics of anticancer vaccines and the results of studies on the clinical efficacy of anticancer vaccines.

References

Kanno A.I., Barbosa M.M.F., Moraes L., Leite L.C.C. SARS-CoV-2 vaccine development and how Brazil is contribu­ting. Genet. Mol. Biol. 2021 Mar 29. 44(1 Suppl 1). e20200320. doi: 10.1590/1678-4685-GMB-2020-0320. PMID: 33818582. PMCID: PMC8020624.

Oladejo M., Paterson Y., Wood L.M. Clinical Experience and Recent Advances in the Development of Listeria-Based Tumor Immunotherapies. Front. Immunol. 2021 Apr 14. 12. 642316. doi: 10.3389/fimmu.2021.642316. PMID: 33936058. PMCID: PMC8081050.

Morse M.A., Gwin W.R., 3rd, Mitchell D.A. Vaccine Therapies for Cancer: Then and Now. Targeted oncology. 2021 Jan 29. 16. 2. 121-152. https://doi.org/10.1007/s11523-020-00788-w.

Bastin D.J., Khan S.T., Montroy J., Kennedy M.A., Forbes N., Martel A.B., Baker L., Gresham L., Boucher D.M., Wong B., Shorr R., Diallo J.S., Fergusson D.A., Lalu M.M., Auer R.C., Kekre N. Safety and efficacy of autologous whole cell vaccines in hematologic malignancies: A systematic review and meta-analysis. Hematol. Oncol. 2021 May 8. doi: 10.1002/hon.2875. Epub ahead of print. PMID: 33963789.

McNeel D.G. Therapeutic Cancer Vaccines: How Much Closer Are We? Biodrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 2018 Feb 32. 1. 1-7. doi: 10.1007/s40259-017-0257-y.

Zarour H.M., DeLeo A., Finn O.J. et al. Categories of Tumor Antigens. In: Kufe D.W., Pollock R.E., Weichselbaum R.R. et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Available from: https://www.ncbi.nlm.nih.gov/books/NBK12961/.

Hollingsworth R.E., Jansen K. Turning the corner on therapeutic cancer vaccines. NPJ Vaccines. 2019 Feb 8. 4. 7. doi: 10.1038/s41541-019-0103-y. PMID: 30774998. PMCID: PMC6368616.

Gulley J.L., Arlen P.M., Madan R.A., Tsang K.Y., Pazdur M.P., Skarupa L., Jones J.L., Poole D.J., Higgins J.P., Hodge J.W., Cereda V., Vergati M., Steinberg S.M., Halabi S., Jones E., Chen C., Parnes H., Wright J.J., Dahut W.L., Schlom J. Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer. Cancer Immunol Immunother. 2010 May. 59(5). 663-74. doi: 10.1007/s00262-009-0782-8. Epub 2009 Nov 5. PMID: 19890632. PMCID: PMC2832083.

Parkhurst M.R., Yang J.C., Langan R.C. et al. T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Molecular Therapy: the Journal of the American Society of Gene Therapy. 2011 Mar. 19(3). 620-626. doi: 10.1038/mt.2010.272.

Garbuglia A.R., Lapa D., Sias C., Capobianchi M.R., Del Porto P. The Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease. Front. Immunol. 2020 Feb 18. 11. 188. doi: 10.3389/fimmu.2020.00188. PMID: 32133000. ­PMCID: PMC7040023.

Nguyen M.H., Wong G., Gane E., Kao J.H., Dusheiko G. Hepatitis B Virus: Advances in Prevention, Diagnosis, and Therapy. Clin. Microbiol. Rev. 2020 Feb 26. 33(2). e00046-19. doi: 10.1128/CMR.00046-19. PMID: 32102898. PMCID: PMC7048015.

Kumai T., Fan A., Harabuchi Y., Celis E. Cancer immunotherapy: moving forward with peptide T cell vaccines. Curr. Opin. Immunol. 2017 Aug. 47. 57-63. doi: 10.1016/j.coi.2017.07.003. Epub 2017 Jul 19. PMID: 28734176. PMCID: PMC5626598.

Gatti-Mays M.E., Redman J.M., Collins J.M., Bilusic M. Cancer vaccines: Enhanced immunogenic modulation through therapeutic combinations. Hum. Vaccin. Immunother. 2017 Nov 2. 13(11). 2561-2574. doi: 10.1080/21645515.2017.1364322. Epub 2017 Aug 31. PMID: 28857666. PMCID: PMC5703410.

Yaddanapudi K., Mitchell R.A., Eaton J.W. Cancer vaccines: Looking to the future. Oncoimmunology. 2013 Mar 1. 2(3). e23403. doi: 10.4161/onci.23403. PMID: 23802081. PMCID: PMC3661166.

Jou J., Harrington K.J., Zocca M.B., Ehrnrooth E., Cohen E.E.W. The Changing Landscape of Therapeutic Cancer Vaccines-Novel Platforms and Neoantigen Identification. Clin. Cancer Res. 2021 Feb 1. 27(3). 689-703. doi: 10.1158/1078-0432.CCR-20-0245. Epub 2020 Oct 29. PMID: 33122346.

Rocconi R.P., Grosen E.A., Ghamande S.A., Chan J.K., Barve M.A., Oh J., Tewari D., Morris P.C., Stevens E.E., Bottsford-Miller J.N., Tang M., Aaron P., Stanbery L., Horvath S., Wallraven G., Bognar E., Manning L., Nemunaitis J., Shanahan D., Slomovitz B.M., Herzog T.J., Monk B.J., Coleman R.L. Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Oncol. 2020 Dec. 21(12). 1661-1672. doi: 10.1016/S1470-2045(20)30533-7. PMID: 33271095.

Constantino J., Gomes C., Falcão A., Cruz M.T., Neves B.M. Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical trials and future perspectives. Transl. Res. 2016 Feb. 168. 74-95. doi: 10.1016/j.trsl.2015.07.008. Epub 2015 Aug 3. PMID: 26297944.

Li D., Romain G., Flamar A.L., Duluc D., Dullaers M., Li X.H., Zurawski S., Bosquet N., Palucka A.K., Le Grand R., O'Garra A., Zurawski G., Banchereau J., Oh S. Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J. Exp. Med. 2012 Jan 16. 209(1). 109-21. doi: 10.1084/jem.20110399. Epub 2012 Jan 2. PMID: 22213806. PMCID: PMC3260876.

Higano C.S., Armstrong A.J., Sartor A.O., Vogelzang N.J., Kantoff P.W., McLeod D.G., Pieczonka C.M., Penson D.F., Shore N.D., Vacirca J., Concepcion R.S., Tutrone R.F., Nord­quist L.T., Quinn D.I., Kassabian V., Scholz M.C., Harmon M., Tyler R.C., Chang N.N., Tang H., Cooperberg M.R. Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer. Cancer. 2019 Dec 1. 125(23). 4172-4180. doi: 10.1002/cncr.32445. Epub 2019 Sep 4. PMID: 31483485. PMCID: PMC6856402.

Antonarakis E.S., Small E.J., Petrylak D.P., Quinn D.I., Kibel A.S., Chang N.N., Dearstyne E., Harmon M., Campogan D., Haynes H., Vu T., Sheikh N.A., Drake C.G. Antigen-Specific CD8 Lytic Phenotype Induced by Sipuleucel-T in Hormone-Sensitive or Castration-Resistant Prostate Cancer and Association with Overall Survival. Clin. Cancer Res. 2018 Oct 1. 24(19). 4662-4671. doi: 10.1158/1078-0432.CCR-18-0638. Epub 2018 Jun 1. PMID: 29858218. PMCID: PMC6481607.

Komura K., Sweeney C.J., Inamoto T., Ibuki N., Azuma H., Kantoff P.W. Current treatment strategies for advanced prostate cancer. Int. J. Urol. 2018 Mar. 25(3). 220-231. doi: 10.1111/iju.13512. Epub 2017 Dec 20. PMID: 29266472. PMCID: PMC6053280.

Neek M., Kim T.I., Wang S.W. Protein-based nanoparticles in cancer vaccine development. Nanomedicine. 2019 Jan. 15(1). 164-174. doi: 10.1016/j.nano.2018.09.004. Epub 2018 Oct 4. PMID: 30291897. PMCID: PMC6289732.

Jorritsma S.H.T., Gowans E.J., Grubor-Bauk B., Wijesundara D.K. Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines. Vaccine. 2016 Nov 4. 34(46). 5488-5494. doi: 10.1016/j.vaccine.2016.09.062. Epub 2016 Oct 11. PMID: 27742218.

Trimble C.L., Morrow M.P., Kraynyak K.A., Shen X., Dallas M., Yan J., Edwards L., Parker R.L., Denny L., Giffear M., Brown A.S., Marcozzi-Pierce K., Shah D., Slager A.M., Sylvester A.J., Khan A., Broderick K.E., Juba R.J., Herring T.A., Boyer J., Lee J., Sardesai N.Y., Weiner D.B., Bagarazzi M.L. Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. Lancet. 2015 Nov 21. 386(10008). 2078-2088. doi: 10.1016/S0140-6736(15)00239-1. Epub 2015 Sep 17. PMID: 26386540. PMCID: PMC4888059.

Kranz L.M., Diken M., Haas H., Kreiter S., Loquai C., Reuter K.C., Meng M., Fritz D., Vascotto F., Hefesha H., Grunwitz C., Vormehr M., Hüsemann Y., Selmi A., Kuhn A.N., Buck J., Derhovanessian E., Rae R., Attig S., Diekmann J., Jabulowsky R.A., Heesch S., Hassel J., Langguth P., Grabbe S., Huber C., Türeci Ö., Sahin U. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature. 2016 Jun 16. 534(7607). 396-401. doi: 10.1038/nature18300. Epub 2016 Jun 1. PMID: 27281205.

Gulley J.L., Borre M., Vogelzang N.J., Ng S., Agarwal N., Parker C.C., Pook D.W., Rathenborg P., Flaig T.W., Carles J., Saad F., Shore N.D., Chen L., Heery C.R., Gerritsen W.R., ­Priou F., Langkilde N.C., Novikov A., Kantoff P.W. Phase III Trial of ­PROSTVAC in Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer. J. Clin. Oncol. 2019 May 1. 37(13). 1051-1061. doi: 10.1200/JCO.18.02031. Epub 2019 Feb 28. PMID: 30817251. PMCID: PMC6494360.

Raja J., Ludwig J.M., Gettinger S.N., Schalper K.A., Kim H.S. Oncolytic virus immunotherapy: future prospects for oncology. J. Immunother Cancer. 2018 Dec 4. 6(1). 140. doi: 10.1186/s40425-018-0458-z. PMID: 30514385. PMCID: PMC6280382.

Milhem M.M., Harrington K.J., Collichio F.A., Amatruda T., Chesney J.A., Agarwala S.S., Puzanov I. Progression-free survival (PFS) in unresectable melanoma patients (pts) treated with talimogene laherparepvec (T-VEC) versus granulocyte macrophage colony-stimulating factor (GM-CSF) in OPTiM, Journal of Clinical Oncology. 2019. 39(15). 9524. https://doi: 10.1200/JCO.2019.37.15_suppl.9524.

Peng M., Mo Y., Wang Y., Wu P., Zhang Y., Xiong F., Guo C., Wu X., Li Y., Li X., Li G., Xiong W., Zeng Z. Neoantigen vaccine: an emerging tumor immunotherapy. Mol. Cancer. 2019 Aug 23. 18(1). 128. doi: 10.1186/s12943-019-1055-6. PMID: 31443694. PMCID: PMC6708248.

Laheru D., Lutz E., Burke J., Biedrzycki B., Solt S., Onners B., Tartakovsky I., Nemunaitis J., Le D., Sugar E., Hege K., Jaffee E. Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin. Cancer Res. 2008 Mar 1. 14(5). 1455-63. doi: 10.1158/1078-0432.CCR-07-0371. PMID: 18316569. PMCID: PMC2879140.

Le D.T., Lutz E., Uram J.N., Sugar E.A., Onners B., Solt S., Zheng L., Diaz L.A. Jr., Donehower R.C., Jaffee E.M., Laheru D.A. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J. Immunother. 2013 Sep. 36(7). 382-9. doi: 10.1097/CJI.0b013e31829fb7a2. PMID: 23924790. PMCID: PMC3779664.

Lutz E., Yeo C.J., Lillemoe K.D., Biedrzycki B., Kobrin B., Herman J., Sugar E., Piantadosi S., Cameron J.L., Solt S., Onners B., Tartakovsky I., Choi M., Sharma R., Illei P.B., Hruban R.H., Abrams R.A., Le D., Jaffee E., Laheru D. A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation. Ann. Surg. 2011 Feb. 253(2). 328-35. doi: 10.1097/SLA.0b013e3181fd271c. PMID: 21217520. PMCID: PMC3085934.

Antonarakis E.S., Eisenberger M.A. Phase III trials with docetaxel-based combinations for metastatic castration-resistant prostate cancer: time to learn from past experiences. J. Clin. Oncol. 2013 May 10. 31(14). 1709-12. doi: 10.1200/JCO.2013.48.8825. Epub 2013 Apr 8. PMID: 23569320. PMCID: PMC4812821.

Faries M.B., Mozzillo N., Kashani-Sabet M., Thompson J.F., Kelley M.C., DeConti R.C., Lee J.E., Huth J.F., Wagner J., Dalgleish A., Pertschuk D., Nardo C., Stern S., Elashoff R., Gammon G., Morton D.L. MMAIT-IV Clinical Trial Group. Long-Term Survival after Complete Surgical Resection and Adjuvant Immunotherapy for Distant Melanoma Metastases. Ann. Surg. Oncol. 2017 Dec. 24(13). 3991-4000. doi: 10.1245/s10434-017-6072-3. Epub 2017 Oct 10. PMID: 29019177.

Liubota R., Cheshuk V., Vereshchako R., Zotov O., Zaichuk V., Anikusko N., Liubota I. The impact of locoregional treatment on survival of patients with primary metastatic breast cancer. Exp. Oncol. 2017 Mar. 39(1). 75-77. PMID: 28361859.

Amato R.J., Hawkins R.E., Kaufman H.L., Thompson J.A., Tomczak P., Szczylik C., McDonald M., Eastty S., Shingler W.H., de Belin J., Goonewardena M., Naylor S., Harrop R. Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study. Clin. Cancer Res. 2010 Nov 15. 16(22). 5539-47. doi: 10.1158/1078-0432.CCR-10-2082. Epub 2010 Sep 29. PMID: 20881001.

Published

2021-08-19

Issue

Section

Review